Granular Cell Tumour of the Larynx

Area of Science:

• Otolaryngology
• Head and Neck Surgery
• Pathology

Background:

• Granular cell tumors (GCTs) are uncommon neoplasms, typically occurring in the head and neck region.
• Laryngeal GCTs are exceedingly rare, posing diagnostic challenges for clinicians.

Observation:

• A 55-year-old female presented with a 6-month history of hoarseness.
• Endoscopic examination revealed a white lesion on the left arytenoid.
• Biopsy confirmed a granular cell tumor, characterized by non-keratinizing stratified squamous epithelium and S-100 positive polygonal cells.

Findings:

• Histopathological examination confirmed the diagnosis of a granular cell tumor.
• The tumor was successfully excised using CO2 laser.
• The histological features of GCT can mimic squamous cell carcinoma.

Implications:

• This case underscores the importance of considering granular cell tumors in the differential diagnosis of laryngeal lesions presenting with hoarseness.
• Awareness among otolaryngologists is crucial for accurate diagnosis and appropriate management, preventing misdiagnosis as malignancy.
• Highlights the utility of S-100 staining in differentiating GCT from other neoplastic entities.