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Liver diseases in heart failure.

Majid Maleki1, Farveh Vakilian2, Ahmad Amin3

  • 1Department of Cardiology, Rajai Cardiovascular, Medical and Research Center, Tehran University of Medical Science, Tehran, Iran.

Heart Asia
|June 22, 2016
PubMed
Summary

Heart failure (HF) impacts liver health, causing hepatic dysfunction that worsens patient outcomes. Understanding this liver involvement is crucial for managing HF and preventing complications.

Keywords:
Ventricular tachycardiacongenital heart diseasecoronary artery diseasefallots tetralogyheart failure treatmentheart failure with normal ejection fractionrisk stratificationsystolic heart failure

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Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Heart failure (HF) is a growing public health concern due to population aging and improved patient survival.
  • HF involves impaired organ perfusion and high filling pressures, affecting multiple organs, notably the liver and kidneys.
  • The liver's complex vasculature and high metabolic activity make it susceptible to circulatory disturbances in HF.

Purpose of the Study:

  • To review the mechanisms and impacts of liver disease in heart failure patients.
  • To provide physicians and cardiologists with a guide on the liver's role in HF.
  • To highlight the significance of hepatic dysfunction in HF prognosis and management.

Main Methods:

  • Literature review focusing on congestive hepatopathy in heart failure.
  • Analysis of studies detailing the impact of liver disease on HF patient outcomes.
  • Examination of molecular and hemodynamic changes in the liver associated with HF.

Main Results:

  • Hepatic dysfunction is frequently observed in HF patients and correlates with poor outcomes.
  • Liver involvement in HF involves significant molecular and hemodynamic alterations.
  • Drug metabolism and potential interactions in the liver are critical considerations for HF pharmacotherapy.

Conclusions:

  • Congestive hepatopathy is a significant complication of heart failure.
  • Understanding liver dysfunction in HF aids in disease staging and treatment.
  • This review serves as a guide for clinicians managing HF patients with liver involvement.