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Updated: Mar 19, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Mean platelet volume and cardiovascular outcomes in acute myocardial infarction
Mangalachulli Pottammal Ranjith1, Rajendran DivyaRaj2, Dolly Mathew3
1Department of Cardiology , Kannur Medical College , Anjarakandy, Kerala , India.
Objective:
High levels of mean platelet volume (MPV) may be associated with adverse outcomes in patients with myocardial infarction (MI). We examined the association between MPV and the risk of death and adverse cardiovascular outcomes in patients with MI.
Methods:
We studied consecutive patients with MI admitted to a tertiary-care hospital during a period of 1 year. MPV was measured at admission and at third month. Patients were followed up for 1-year primary composite outcome of cardiovascular death, stroke, fatal or non-fatal MI and cardiac failure. Patients were classified according to tertile of baseline MPV.
Results:
A total of 1206 patients with MI, including 934 men (77.4%) and 272 women (22.6%) were studied. The mean age of the study population was 56 years. At 1-year follow-up, 292 (28.57%) primary outcome occurred: cardiovascular mortality 78 (7.6%), fatal or non-fatal MI 153 (15.0%), stroke 30 (2.9%) and cardiac failure 128 (12.52%). Patients with the highest tertile MPV had higher primary outcome as compared with those with MPV in the lowest tertile (adjusted OR=2.31; 95% CI 1.60 to 3.35; p<0.001). Total mortality was also more in high-MPV group (adjusted OR 2.62; 95% CI 1.47 to 4.70; p<0.001). There were no significant changes in mean MPV values at admission from those at third month interval (9.15, (SD 0.99) vs 9.19 (SD 0.94); p=0.2).
Conclusions:
Elevated MPV was associated with worse outcome in patients with acute MI. Elevated MPV in these patients may be due to inherently large platelets.
Trial Registration Number:
http://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=5485&EncHid=98036.61144&modid=1&compid=19; CTRI/2012/12/003222.
Insights
Elevated mean platelet volume (MPV) in patients with myocardial infarction (MI) is linked to worse outcomes. This finding suggests larger platelets may indicate higher cardiovascular risk in MI patients.
Area of Science:
- Cardiology
- Hematology
- Clinical Research
Background:
- High mean platelet volume (MPV) is potentially linked to adverse outcomes in myocardial infarction (MI) patients.
- Platelet characteristics, including MPV, play a role in cardiovascular disease pathogenesis.
- Understanding MPV's prognostic value can aid in risk stratification for MI patients.
Purpose of the Study:
- To investigate the association between MPV levels and the risk of death and adverse cardiovascular outcomes in patients following MI.
- To determine if baseline MPV is a predictor of long-term cardiovascular events in MI survivors.
Main Methods:
- A cohort of 1206 consecutive MI patients was studied.
- Mean platelet volume (MPV) was measured at hospital admission and at the third month post-admission.
- Patients were followed for one year to assess a composite outcome including cardiovascular death, stroke, recurrent MI, and cardiac failure, categorized by baseline MPV tertiles.
Main Results:
- Patients in the highest MPV tertile exhibited a significantly higher risk of the primary composite outcome (adjusted OR=2.31) and total mortality (adjusted OR=2.62) compared to those in the lowest tertile.
- The study included 1206 MI patients (77.4% men, mean age 56 years).
- No significant changes in MPV were observed between admission and the third month (9.15 vs. 9.19).
Conclusions:
- Elevated MPV is associated with worse clinical outcomes in patients diagnosed with acute myocardial infarction.
- The presence of inherently large platelets, indicated by elevated MPV, may contribute to adverse cardiovascular events post-MI.
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