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Updated: Mar 19, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19

Aurélie Mallinger1, Kai Schiemann2, Christian Rink1

  • 1Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research , London SW7 3RP, UK.

ACS Medicinal Chemistry Letters
|June 22, 2016
PubMed

Keywords:
CDK19CDK8aldehyde oxidasekinase inhibitormediator complex

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