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Related Concept Videos

Brain Imaging01:14

Brain Imaging

895
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
895

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Related Experiment Video

Updated: Mar 19, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
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Interventional MR Imaging for Deep-Brain Stimulation Electrode Placement.

Thanissara Chansakul1, Paul N Chen1, Thomas C Lee1

  • 1From the Department of Radiology, Division of Neuroradiology (T.C., P.N.C., T.C.L.), and Department of Neurosurgery (T.T.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.

Radiology
|June 22, 2016
PubMed
Summary
This summary is machine-generated.

Interventional magnetic resonance (MR) imaging-guided deep-brain stimulation (DBS) electrode placement is a safe and effective alternative for select patients. This method offers precise targeting without traditional surgical frames, showing minimal errors and successful outcomes.

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Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Neurology

Background:

  • Traditional frame-based surgery for deep-brain stimulation (DBS) can be challenging due to patient factors like dystonia or inability to tolerate awake surgery.
  • Anatomic anomalies may increase bleeding risks with microelectrode mapping during conventional DBS placement.

Purpose of the Study:

  • To evaluate the safety and accuracy of DBS electrode placement using interventional magnetic resonance (MR) imaging.
  • To assess targeting errors and clinical outcomes in patients undergoing MR-guided DBS surgery.

Main Methods:

  • Retrospective analysis of 10 patients (19 electrodes) who underwent interventional MR imaging-guided DBS for movement disorders.
  • Evaluation of perioperative complications (hemorrhage, stroke, death) and electrode functionality at 2 weeks post-operation.
  • Calculation of mean radial and trajectory errors for electrode placement accuracy.

Main Results:

  • No intraoperative neurologic complications were observed in the 10 patients.
  • One patient experienced postoperative aspiration pneumonia; all leads provided clinically effective stimulation.
  • Mean radial error was 0.7 mm ± 0.4, and mean trajectory error was 0.5 mm ± 0.4.

Conclusions:

  • Interventional MR imaging-guided DBS electrode placement is a safe and effective alternative for carefully selected patients.
  • This technique may overcome limitations associated with traditional frame-based DBS surgery.
  • The study demonstrates high accuracy and good clinical outcomes for MR-guided DBS.