Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of Poliosis in Patients Treated With Immunotherapy for Metastatic Cutaneous and Non-Cutaneous Melanoma.

Pigment cell & melanoma research·2026

Same author

mGluR6 coordinates cone terminal targeting and synaptic layer assembly during human retinal development.

bioRxiv : the preprint server for biology·2026

Same author

Modeled Aqueous Humor Protein Concentrations to Enable Biomarker Development in Uveal Melanoma.

International journal of molecular sciences·2026

Same author

Saving the Eye, Counting the Cost: Rethinking Treatment Burden in Unilateral Retinoblastoma.

Clinical & experimental ophthalmology·2026

Same author

The use of aqueous humor cfDNA for low-pass whole genome sequencing as a clinical test to identify intraocular retinoblastoma recurrence.

ScienceBank·2026

Same author

Cognition and Anesthesia Exposure in Adolescent and Young Adult Retinoblastoma Survivors.

Paediatric anaesthesia·2026

Same journal

Persistent placoid maculopathy: long term outcomes and prognostic factors.

Retina (Philadelphia, Pa.)·2026

Same journal

ANTI-VEGF THERAPY SWITCHING RETINAL DISEASES: Characterizing Clinical Manifestations and Common Involved Genes: ERRATUM.

Retina (Philadelphia, Pa.)·2026

Same journal

THE EFFICACY AND SAFETY OF SUBRETINAL BALANCED SALT SOLUTION INJECTION IN DIABETIC MACULAR EDEMA WITH HARD EXUDATES: ERRATUM.

Retina (Philadelphia, Pa.)·2026

Same journal

EVALUATING CLINICAL OUTCOMES OF AMNIOTIC MEMBRANE COVERAGE COMBINED WITH EARLY VITRECTOMY IN THE MANAGEMENT OF PERFORATING GLOBE INJURIES.

Retina (Philadelphia, Pa.)·2026

Same journal

Mid-Phase Hyperfluorescent Plaques as a biomarker of disease activity in Central Serous Chorioretinopathy: Clinical Course and Treatment Response - MICRoN report number Ten.

Retina (Philadelphia, Pa.)·2026

Same journal

Severe retinal non-perfusion is associated with fewer retinal lesions on ultra-wide field fundus photography in proliferative diabetic retinopathy.

Retina (Philadelphia, Pa.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 27, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Transcorneal Vitrectomy In Eyes With Regressed Retinoblastoma.

Yicheng K Bao¹, Gisella M Sanchez², Thomas C Lee^1,2

¹Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California; and.

Retina (Philadelphia, Pa.)

|January 9, 2025

Summary

This summary is machine-generated.

A novel transcorneal vitrectomy technique offers a chemotherapy-free and cryotherapy-free surgical option for regressed retinoblastoma. This approach facilitates globe salvage while managing vitreoretinal complications and shows promise in avoiding further treatments.

More Related Videos

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Related Experiment Videos

Last Updated: May 27, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Area of Science:

Ophthalmology
Oncology
Surgical Innovation

Background:

Current retinoblastoma treatments can lead to vitreoretinal disorders requiring surgery.
Surgical approaches for retinoblastoma remain a subject of debate.
This study explores an alternative surgical method for managing eyes with regressed retinoblastoma.

Purpose of the Study:

To describe a transcorneal vitrectomy technique for eyes with regressed retinoblastoma.
To evaluate the safety and efficacy of this approach in avoiding chemotherapy or cryotherapy.
To assess surgical outcomes and oncological safety.

Main Methods:

Retrospective chart review of five patients with regressed retinoblastoma (Group D/ct2b) who underwent vitrectomy.
Utilized a transcorneal vitrectomy approach with radially oriented corneal incisions and top-down visualization.
No chemotherapy or cryotherapy was administered; a postsurgical water rinse was performed to lyse potential retinoblastoma cells.

Main Results:

Eight vitrectomies were performed for indications including IOL fibrosis, vitreous hemorrhage, cataract, retinal detachment, and silicone oil removal.
Surgical objectives were achieved with stable vision and no evidence of retinoblastoma spread.
Mean follow-up was 7.6 months, with no recurrence noted.

Conclusions:

The described transcorneal vitrectomy technique allows for top-down viewing and avoids suturing through the uveal tract.
A postsurgical water rinse may help eliminate residual retinoblastoma cells.
This approach presents a potential alternative to chemotherapy or cryotherapy in managing regressed retinoblastoma.