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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Related Experiment Video

Updated: Mar 19, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

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Delayed-onset dementia after stroke or transient ischemic attack.

Vincent C T Mok1, Bonnie Y K Lam1, Zhaolu Wang2

  • 1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; Therese Pei Fong Chow Research Centre for Prevention of Dementia, Hong Kong SAR, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|June 22, 2016
PubMed
Summary

Patients surviving stroke face a high risk of developing dementia later. Severe small vessel disease (SVD) significantly predicts this delayed-onset dementia, suggesting targeted prevention strategies.

Keywords:
Alzheimer's diseaseDelayed-onset dementiaSmall vessel diseaseStrokeTransient ischemic attack

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Area of Science:

  • Neurology
  • Vascular Neurology
  • Neurodegenerative Diseases

Background:

  • Patients surviving stroke without immediate dementia are at significant risk for developing dementia later.
  • The mechanisms underlying delayed-onset dementia are complex, involving vascular and neurodegenerative factors.

Purpose of the Study:

  • To investigate predictors of delayed-onset dementia in patients who have experienced stroke or transient ischemic attack (TIA).
  • To identify specific markers associated with the development of dementia post-stroke.

Main Methods:

  • A prospective study followed 919 dementia-free patients with stroke/TIA for 3 years.
  • Exclusion criteria included dementia onset within 3-6 months post-stroke/TIA.
  • Predictors were assessed including imaging markers of small vessel disease (SVD), hypertension, and diabetes.

Main Results:

  • 4.4% of subjects developed dementia during the study.
  • Severe SVD (≥3 lacunes, confluent white matter changes), hypertension, and diabetes independently predicted delayed-onset dementia.
  • Alzheimer's disease-like Pittsburg compound B (PiB) retention was present in only 19.4% of those with cognitive decline, and most of these cases also showed severe SVD.

Conclusions:

  • Severe SVD is a major contributor to delayed-onset dementia following stroke/TIA.
  • Clinical trials should focus on high-risk individuals, particularly those with SVD, to prevent delayed-onset dementia.