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Intracardiac impedance response during acute AF internal cardioversion using novel rectilinear and
A S Rababah1, S J Walsh, G Manoharan
1School of Engineering, Engineering Research Institute, Ulster University, Newtownabbey, UK.
Physiological Measurement
|June 22, 2016
Summary
Intracardiac impedance (ICI) dynamics during atrial fibrillation cardioversion are key to success. New impedance parameters, intracardiac impedance variance (ICIV) and impedance amplitude spectrum area (IAMSA), show promise as prognostic markers.
Area of Science:
- Cardiovascular Electrophysiology
- Medical Signal Processing
Background:
- Intracardiac impedance (ICI) is crucial for successful internal cardioversion of atrial fibrillation (AF).
- Limited research exists on dynamic atrial impedance behavior during cardioversion and its relation to clinical outcomes.
Purpose of the Study:
- To investigate the dynamic behavior of atrial impedance during internal cardioversion.
- To analyze novel radiofrequency (RF) and conventional capacitor-discharge shock waveforms.
- To correlate impedance parameters with cardioversion success and energy delivery.
Main Methods:
- Retrospective analysis of voltage and current waveforms from ovine models undergoing internal cardioversion of acute AF.
- Utilized a digital signal processing algorithm for simultaneous analysis of multiple impedance parameters (mean intracardiac impedance (Z M), intracardiac impedance variance (ICIV), impedance amplitude spectrum area (IAMSA)).
Main Results:
- A significant reduction in ICI was observed between successive shocks in successful cardioversion events.
- Intracardiac impedance variance (ICIV) and impedance amplitude spectrum area (IAMSA) inversely correlated with delivered energy, with ICIV showing a stronger correlation.
- These dynamic impedance parameters offer insights into the cardioversion process.
Conclusions:
- Intracardiac impedance variance (ICIV) and impedance amplitude spectrum area (IAMSA) are significant dynamic ICI variables.
- These parameters may enhance understanding of the cardioversion mechanism.
- ICIV and IAMSA show potential as prognostic markers for clinical outcomes in AF cardioversion.
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