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Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct

S K Ashcroft1, K Basclain1, C Woolnough2

  • 1School of Behavioural and Health Sciences, Australian Catholic University, Strathfield, New South Wales, Australia.

Journal of Neuroscience Research
|June 24, 2025
PubMed
Summary
This summary is machine-generated.

This study found that while brain-derived neurotrophic factor (BDNF) and lactate levels increase after exercise, they are not significantly correlated overall. However, a correlation was noted in specific groups, including males and those with the Val66Met polymorphism.

Keywords:
biomarkerbrain‐derived neurotrophic factorexerciselactateneuroplasticity

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Area of Science:

  • Exercise Physiology
  • Neuroscience
  • Genetics

Background:

  • Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal plasticity and is influenced by physical activity.
  • Lactate is a metabolic byproduct of anaerobic exercise, and its concentration changes significantly with exercise intensity.
  • The Val66Met polymorphism in the BDNF gene may affect BDNF secretion and response to stimuli.

Purpose of the Study:

  • To investigate the relationship between BDNF and lactate concentrations before and after a submaximal graded exercise test.
  • To examine how the Val66Met polymorphism and sex influence the BDNF-lactate relationship during exercise.

Main Methods:

  • 31 adults underwent a submaximal graded exercise test.
  • BDNF and lactate concentrations were measured pre- and post-exercise.
  • Genotyping for the Val66Met polymorphism was performed.
  • Pearson's correlation coefficient was used to analyze the relationship between BDNF and lactate.

Main Results:

  • Both BDNF and lactate concentrations significantly increased post-exercise (p < 0.001).
  • No significant correlation was found between BDNF and lactate overall (pre-exercise: r = -0.256, p = 0.164; post-exercise: r = 0.112, p = 0.549; change: r = 0.019, p = 0.921).
  • A moderate inverse correlation between BDNF and lactate was observed pre-exercise in individuals with the Val66Met polymorphism (r = -0.744, p = 0.009) and in males (r = -0.695, p = 0.006).

Conclusions:

  • Submaximal graded exercise increases both BDNF and lactate levels.
  • There is limited evidence for a direct correlation between BDNF and lactate concentrations in the general population after exercise.
  • The Val66Met polymorphism and sex may modulate the relationship between BDNF and lactate during exercise.