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Updated: Mar 19, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
Portable infrared pupillometry in critical care
Merlin D Larson1,2, Vineeta Singh3
1Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, 94143, USA. larsonm@anesthesia.ucsf.edu.
Portable infrared pupillometry devices are now available for hospital use. Studies confirm their accuracy compared to traditional methods, highlighting their potential in critical care patient monitoring.
Area of Science:
- Ophthalmology
- Critical Care Medicine
- Medical Instrumentation
Background:
- Infrared pupillometry technology was developed in 1962.
- Portable infrared pupillometry devices are recent innovations in healthcare.
- Concerns about accuracy have been investigated through observer agreement and comparisons with standard pen-light examinations.
Purpose of the Study:
- To summarize the evolution of portable infrared pupillometry devices.
- To provide an overview of the accuracy of these new instruments.
- To explore the potential applications of pupillary assessment in critical care.
Main Methods:
- Review of the development of infrared pupillometry technology.
- Analysis of studies documenting inter-observer agreement for pupillary measurements.
- Comparison of infrared pupillometry with standard pen-light examinations.
Main Results:
- Portable infrared pupillometry instruments have recently become available for clinical settings.
- Studies indicate acceptable accuracy and inter-observer agreement for these devices.
- The pupil's function offers valuable insights into patient status.
Conclusions:
- Portable infrared pupillometry devices are a validated tool for clinical use.
- These devices can aid in the assessment and management of critically ill patients.
- Pupillary reflex monitoring holds significant promise for enhancing patient care in critical illness.
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