Related Experiment Video
Updated: Mar 19, 2026
07:05
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
22.1K
Circulating Progenitor Cells in Regenerative Technologies: A Realistic Strategy in Bone Regeneration?
Jessica B Chang1, Justine C Lee1
1Division of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA.
International Journal of Stem Cell Research and Therapy
|June 23, 2016
Summary
This review explores using circulating progenitor cells for bone regeneration. Research indicates these cells show potential for osteogenesis and mineralization in skeletal repair studies.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Orthopedics
Background:
- Skeletal regeneration research traditionally focuses on cells, biomaterials, and growth factors.
- Peripheral blood contains circulating progenitor cells, raising interest in their regenerative potential.
Purpose of the Study:
- To review the current literature on the use of circulating progenitor cells in bone regeneration.
- To evaluate the osteogenic and mineralization capabilities of these cells.
Main Methods:
- Comprehensive literature review of in vitro and in vivo studies.
- Analysis of studies investigating circulating progenitor cells for skeletal repair.
Main Results:
- Circulating progenitor cells are being investigated for their role in bone healing.
- Evidence suggests potential for osteogenesis and mineralization, though further research is needed.
Conclusions:
- Circulating progenitor cells represent a promising, accessible source for skeletal regeneration.
- Further investigation is warranted to optimize their use in clinical applications for bone repair.
More Related Videos
11:37Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
Published on: June 18, 2018
7.1K
05:32In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
Published on: February 16, 2024
1.0K
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
01:19Multipotency of Hematopoietic Stem Cells
4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
01:21Hematopoiesis
9.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.7K
01:30Bone Cells and Tissue
10.1K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
10.1K
01:01Regulation of Hematopoietic Stem Cells
4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
01:34Production of Formed Elements
5.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...
5.3K