Related Experiment Video
Updated: Mar 19, 2026
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Impaired executive functions in experimental model of temporal lobe epilepsy
Fabiane Ochai Ramos1,2, Luiz Renato Rodrigues Carreiro1, Fulvio Alexandre Scorza2
1Universidade Presbiteriana Mackenzie, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, São Paulo SP , Brasil, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, Programa de Pós-Graduação em Distúrbios do Desenvolvimento, São Paulo SP, Brasil;
Objective:
The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE).
Method:
Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal.
Results:
Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory.
Conclusion:
Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.
