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Updated: Mar 19, 2026

Preparation of Quality Inositol Pyrophosphates
Published on: September 3, 2011
A Chiral Phosphoramidite Reagent for the Synthesis of Inositol Phosphates
Estelle Durantie1, Samuel Huwiler1, Jean-Christophe Leroux1
1Department of Chemistry and Applied Biosciences, ETH-Zürich , 8093 Zürich, Switzerland.
Abstract:
There is a paucity of chiral phosphoramidite reagents or chiral catalysis methods for the synthesis of biologically relevant inositol phosphates. A new C2-symmetrical chiral phosphoramidite has been developed and successfully applied to the synthesis of a set of chiral inositol bisphosphates. The reagent allowed bis-phosphorylation and chiral resolution, resulting in a concise synthetic route, thus expanding the toolbox available for the preparation of biologically relevant inositol phosphates in high optical purity.
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