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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

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The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

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Published on: September 23, 2018

[Regenerative therapy for post-stroke patients].

Toru Yamashita, Koji Abe

Nihon Rinsho. Japanese Journal of Clinical Medicine

|June 24, 2016

Summary

Cell replacement therapy offers a promising strategy for stroke recovery. Researchers are exploring novel stem cell sources and reprogramming techniques to improve safety and efficacy for future clinical applications.

Area of Science:

Regenerative Medicine
Neuroscience
Stem Cell Biology

Context:

Stroke remains a leading cause of long-term disability, necessitating innovative therapeutic approaches.
Current cell replacement therapies face challenges in sourcing safe and effective cells.
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) show promise due to their pluripotency and replication capacity.

Purpose:

To discuss the advantages and challenges of using stem cells for post-stroke cell replacement therapy.
To explore novel methods for generating neuronal cells and neural stem cells from somatic cells.
To evaluate the potential for clinical application of these advanced cell sources.

Summary:

Investigates the use of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) for stroke cell replacement therapy.

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Last Updated: Mar 19, 2026

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Highlights recent advancements in using transcriptional factors to convert somatic cells into neuronal cells and neural stem cells without requiring embryonic stem cell fate.

Discusses the benefits, limitations, and clinical applicability of these cell sources for stroke patients.

Impact:

Advances the field of regenerative medicine for neurological disorders.
Provides insights into developing safer and more effective cell-based treatments for stroke.
Paves the way for potential clinical translation of novel stem cell therapies in stroke recovery.