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The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
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Relationship Between Lung Cancer and Mycobacterium Avium Complex Isolated Using Bronchoscopy
Atsuhisa Tamura1, Akira Hebisawa2, Kei Kusaka3
1Center for Pulmonary Diseases and Respiratory Disease Division, National Hospital Organization Tokyo National Hospital, Kiyose, Tokyo 204-8585, Japan; Clinical Research Center and Pathology Division, National Hospital Organization Tokyo National Hospital, Kiyose, Tokyo 204-8585, Japan.
The Open Respiratory Medicine Journal
|June 24, 2016
Summary
Mycobacterium avium complex (MAC) positive cultures in bronchial washings are linked to lung cancer. This association was more common in older women, but lung cancer specifics did not influence MAC infection.
Area of Science:
- Pulmonology
- Infectious Diseases
- Oncology
Background:
- The global incidence of Mycobacterium avium complex (MAC)-positive respiratory cultures and subsequent MAC lung disease (MACLD) is rising.
- This trend necessitates investigating potential associations between MAC infections and other pulmonary conditions.
Purpose of the Study:
- To determine the association between MAC-positive bronchoscopy specimens and the presence of lung cancer.
- To identify patient characteristics associated with MAC infection in lung cancer patients.
Main Methods:
- A retrospective review of 1258 untreated lung cancer patients who underwent bronchoscopy and mycobacterial culture between 2003 and 2011.
- Comparison of patient demographics and clinical features between MAC-positive and MAC-negative lung cancer groups.
- Assessment of MACLD status and subsequent development of MACLD in patients with lung cancer.
Main Results:
- 2.0% of lung cancer patients (25/1258) had MAC-positive bronchial washings.
- MAC-positive lung cancer patients were significantly more likely to be female (52% vs. 30%) and older (72 vs. 69 years) compared to MAC-negative patients.
- No significant differences in patient characteristics were observed between lung cancer patients with and without MACLD; no patients without MACLD developed it subsequently.
Conclusions:
- MAC-positive bronchial washing is positively associated with lung cancer.
- Female sex and advanced age are associated with MAC infection in lung cancer patients.
- Lung cancer characteristics were not found to be associated with MAC infection.
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