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Related Experiment Videos

Urinary 3-methylhistidine excretion increases with repeated weight training exercise.

J M Pivarnik1, J F Hickson, I Wolinsky

  • 1Department of Health, Physical Education, and Recreation and University of Houston TX.

Medicine and Science in Sports and Exercise
|June 1, 1989
PubMed
Summary

Progressive resistance weight training significantly increased urinary 3-methylhistidine (3-MH) in untrained men. This indicates that skeletal muscle degradation rises during strength-building exercise.

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Area of Science:

  • Exercise Physiology
  • Biochemistry
  • Sports Science

Background:

  • Urinary 3-methylhistidine (3-MH) is a biomarker for skeletal muscle protein breakdown.
  • The impact of resistance training on muscle catabolism in untrained individuals requires further investigation.

Purpose of the Study:

  • To investigate the effect of progressive resistance weight training on urinary 3-methylhistidine (3-MH) excretions.
  • To determine if skeletal muscle degradation increases during the initial phase of strength-building exercise.

Main Methods:

  • 11 untrained males participated in a 19-day study.
  • A lactovegetarian diet meeting protein requirements was provided.
  • Subjects underwent strength testing and 12 days of upper and lower body weight training.

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  • Daily 24-hour urine collections were analyzed for 3-MH and creatinine.

    • Main Results:

    • Baseline 3-MH levels were stable during a 7-day pre-exercise period.
    • Urinary 3-MH significantly increased by day 11 (third day of training).
    • Increases were consistent across various expression methods (per day, per body weight, per creatinine).

    Conclusions:

    • Progressive resistance weight training elevates skeletal muscle catabolism.
    • The rate of skeletal muscle degradation increases during the early stages of strength-building exercise.