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Hydrolyzed Proteins in Allergy.

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    Hydrolyzed formulas help manage infant allergies. Extensively hydrolyzed formulas are best for cow

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    Area of Science:

    • Allergy and Immunology
    • Pediatric Nutrition
    • Gastroenterology

    Background:

    • Hydrolyzed proteins are crucial for managing infant allergic conditions and preventing allergies in high-risk infants.
    • Different hydrolyzed formulas (HFs) vary in hydrolysis degree, method, protein source, and non-nitrogen components, influencing efficacy, tolerance, and nutrition.
    • Cow's milk (CM)-based HFs are categorized as extensively (eHF) or partially (pHF) hydrolyzed.

    Purpose of the Study:

    • To review the role and characteristics of hydrolyzed formulas in infant allergy management and prevention.
    • To discuss the efficacy of different hydrolyzed formulas, including whey pHF, eHF, and emerging rice protein-based options.

    Main Methods:

    • Literature review and analysis of existing studies on hydrolyzed formulas for infant allergy.
    • Classification of hydrolyzed formulas based on protein source and hydrolysis extent.
    • Evaluation of clinical evidence for therapeutic and preventive effects.

    Main Results:

    • Whey partially hydrolyzed formula (pHF) has demonstrated efficacy in reducing atopic dermatitis in non-exclusively breastfed, high-risk infants.
    • Extensively hydrolyzed formulas (eHFs) are currently the primary treatment for most infants with cow's milk allergy (CMA).
    • Newer options like extensively hydrolyzed rice protein-based formulas show promise as cost-effective alternatives, pending confirmation of safety and efficacy.

    Conclusions:

    • Hydrolyzed formulas are essential in infant allergy management, with eHFs being the standard for CMA treatment.
    • Further research is needed to establish the preventive role of hydrolyzed formulas, particularly in the general infant population.
    • Innovations in hydrolyzed formulas, such as rice-based options, offer potential alternatives requiring further validation.