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Association between Body Mass Index and All-Cause Mortality in Hypertensive Adults: Results from the China Stroke

Wei Yang1, Jian-Ping Li2, Yan Zhang3

  • 1Department of Cardiology, Peking University First Hospital, Beijing 100034, China. ywyy2008@163.com.

Nutrients
|June 25, 2016
PubMed

Insights

For hypertensive Chinese adults, being underweight significantly increases mortality risk. However, overweight and obesity are linked to lower all-cause mortality, with grade 1 obesity showing the lowest risk.

Area of Science:

  • Cardiovascular Health
  • Epidemiology
  • Public Health

Background:

  • Elevated body mass index (BMI) is linked to mortality risk in general populations.
  • The specific association between BMI and all-cause mortality in hypertensive Chinese adults is not well-established.

Purpose of the Study:

  • To investigate the relationship between BMI and all-cause mortality among hypertensive Chinese adults.
  • To determine optimal BMI ranges for reduced mortality in this demographic.

Main Methods:

  • Post-hoc analysis of data from the China Stroke Primary Prevention Trial (CSPPT).
  • Cox regression analysis to assess the association between BMI categories and all-cause mortality.
  • Follow-up duration of 4.5 years with 20,694 participants aged 45-75 years.

Main Results:

  • A reversed J-shaped relationship was observed between BMI and all-cause mortality.
  • Underweight (BMI <18.5 kg/m²) was associated with significantly higher mortality (HR 1.56).
  • Overweight (24.0-27.9 kg/m²) and obesity (≥28.0 kg/m²) were associated with lower mortality (HRs 0.78 and 0.64, respectively).
  • Participants over 60 had optimal BMI in the obesity classification, consistent across sexes.

Conclusions:

  • Underweight status poses a significant mortality risk for hypertensive Chinese adults.
  • Overweight and obesity are not associated with increased mortality and may be protective in this population.
  • Grade 1 obesity appears to be associated with the lowest all-cause mortality in hypertensive Chinese adults.

Keywords:
Chinabody mass indexhypertensionmortalityobesity

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