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Relaxin-2 expression in oral squamous cell carcinoma
Gino Marioni1, Roberto Di Carlo1, Giancarlo Ottaviano1
1Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy.
The International Journal of Biological Markers
|June 25, 2016
Summary
Relaxin-2 expression in oral squamous cell carcinoma (OSCC) correlates with invasion patterns and recurrence risk. Higher relaxin-2 levels in OSCC tissue may indicate a poorer prognosis, suggesting its potential as a predictive biomarker.
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- Oral squamous cell carcinoma (OSCC) with bone invasion has a worse prognosis.
- Human relaxin-2, a peptide hormone, may drive tumor-induced osteolysis.
- This study assesses the prognostic role of relaxin-2 in OSCC and adjacent bone.
Purpose of the Study:
- To evaluate the prognostic significance of relaxin-2 expression in OSCC.
- To determine the association between relaxin-2 levels and tumor invasion patterns.
- To investigate the relationship between relaxin-2 expression and cancer recurrence.
Main Methods:
- Immunohistochemical analysis of relaxin-2 expression and intensity.
- Assessment in tumor and adjacent bone specimens from 23 OSCC patients.
- Correlation of relaxin-2 levels with invasion patterns and recurrence data.
Main Results:
- All OSCC specimens tested positive for relaxin-2.
- Higher relaxin-2 reaction intensity correlated with an infiltrative tumor invasion pattern (p=0.02).
- Mean relaxin-2 expression was significantly higher in patients with OSCC recurrence (p=0.049).
Conclusions:
- Relaxin-2 expression in OSCC may serve as a prognostic marker for recurrence risk.
- Patients with higher relaxin-2 levels might benefit from closer monitoring and aggressive therapy.
- Further research into relaxin-2 antagonists could offer novel therapeutic strategies for cancer growth limitation.
