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Updated: Mar 19, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
The utility of noninvasive nasal positive pressure ventilators for optimizing oxygenation during rapid sequence
Tae Hoon Kim1, Sung Oh Hwang2, Yong Sung Cha2
1Department of Emergency Medicine, Busan Baik Hospital, Inje University, Republic of Korea.
Objectives:
The objective of the study is to investigate the feasibility of noninvasive nasal positive pressure ventilation (NINPPV) for optimizing oxygenation during the rapid sequence intubation in critically ill patients.
Methods:
A prospective, observational study was performed in an emergency department. Noninvasive nasal positive pressure ventilation was applied in the preoxygenation step and maintained until successful intubation. A pulse oximetry (Spo2) was continuously monitored throughout the procedure and recorded 5 times. The degree of interfering was surveyed with 10-point Likert scale.
Results:
Thirty patients were enrolled. The most of enrolled patients were diagnosed as pneumonia, acute heart failure, and traumatic brain injury. The Spo2 was increased to 100% (98%-100%) at the time of starting endotracheal intubation with NINPPV and maintained as 97% (95%-100%) until successful intubation (P< .001). Total apnea duration was 195 seconds (190-196). The degree of interfering intubation was 1 (0-1).
Conclusions:
Noninvasive nasal positive pressure ventilation would be useful for optimizing oxygenation during rapid sequence intubation.
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