Casein phosphopeptide-amorphous calcium phosphate products in caries prevention

Area of Science:

• Dental Science
• Caries Prevention
• Remineralization Therapy

Background:

• Dental caries remains a significant public health concern.
• Casein phosphopeptide-amorphous calcium phosphate (CCP-ACP) products like Tooth Mousse are used for caries management.
• Evidence on the efficacy of Tooth Mousse compared to standard fluoride treatments is evolving.

Purpose of the Study:

• To systematically review clinical trials on the efficacy of Tooth Mousse and Tooth Mousse Plus in preventing and treating dental caries.
• To compare the effectiveness of Tooth Mousse formulations against routine oral care, particularly fluoride toothpaste.

Main Methods:

• Systematic review of randomized controlled trials (RCTs) from Medline, Embase, PreMedline, and Cochrane Central Register.
• Studies focused on clinical caries outcomes, comparing Tooth Mousse/Plus to routine care.
• Exclusion of studies using other CCP-ACP formulations or split-mouth designs; English language papers only.

Main Results:

• Three low-risk-of-bias studies found no significant benefit of Tooth Mousse over fluoride toothpaste for caries prevention.
• Nine studies with high risk of bias indicated potential for white spot lesion regression in orthodontic patients.
• Tooth Mousse Plus showed no added benefit over standard Tooth Mousse; evidence for both is limited.

Conclusions:

• No evidence supports Tooth Mousse over fluoride toothpaste for preventing early caries.
• Tooth Mousse may benefit regression of white spot lesions in orthodontic patients, but evidence is limited.
• High-quality RCTs are needed to establish recommendations for Tooth Mousse products in caries prevention and treatment.