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Updated: Mar 19, 2026

Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
Unusual case of non-resolving necrotizing pneumonia: A last resort measure for cure
Naseem Salahuddin1, Naila Baig-Ansari2, Saulat Hasnain Fatimi3
1Department of Medicine, The Aga Khan University Hospital, Department of Infectious Diseases, The Indus Hospital, Karachi.
Abstract:
To our knowledge, this is an unusual case of a community-acquired pneumonia (CAP) with sepsis secondary to Streptococcus pneumoniae that required lung resection for a non-resolving consolidation. A 74 year old previously healthy woman, presented with acute fever, chills and pleuritic chest pain in Emergency Department (ED). A diagnosis of CAP was established with a Pneumonia Severity Index CURB-65 score of 5/5. In the ER, she was promptly and appropriately managed with antibiotics and aggressive supportive therapy. She remained on ten days of intravenous antibiotics. However, 48 hours post antibiotic course, she returned to ER with fever and signs of sepsis. Despite timely and appropriate management, the consolidated lobe remained the focus of sepsis for over four weeks. The patient recovered after the offending lobe was resected. Histopathology of the lung tissue revealed acute and chronic inflammation. However, no malignancy, bacterial infection or broncho-pleural fistula was found. Eighteen months post-surgery, the patient remains well.
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