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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

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Treating osteoporosis.

Akhil Gupta1, Lyn March2

  • 1Royal North Shore Hospital, Sydney.

Australian Prescriber
|June 25, 2016
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Summary
This summary is machine-generated.

Osteoporotic fractures are a significant health concern. Tailored exercise, adequate calcium and vitamin D, and appropriate medications like bisphosphonates are key to managing and preventing osteoporosis.

Keywords:
bisphosphonatesbone resorption inhibitorcalciumvitamin D

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Area of Science:

  • Gerontology
  • Orthopedics
  • Endocrinology

Background:

  • Osteoporotic fractures are a major cause of morbidity and mortality.
  • Exercise is crucial for both preventing osteoporosis and managing the condition in patients.
  • Dietary calcium and sun-derived vitamin D are important, with supplements sometimes necessary.

Purpose of the Study:

  • To review current strategies for osteoporosis prevention and management.
  • To highlight the role of exercise, nutrition, and pharmacotherapy.

Main Methods:

  • Review of current literature on osteoporosis management.
  • Discussion of pharmacological treatments including bisphosphonates, denosumab, raloxifene, strontium ranelate, and teriparatide.
  • Emphasis on individualized exercise and nutritional recommendations.

Main Results:

  • Exercise must be tailored to individual osteoporosis patients.
  • First-line pharmacotherapy includes bisphosphonates and denosumab.
  • Alternative medications and treatments for severe osteoporosis are discussed, with a note on declining strontium ranelate use due to safety concerns.

Conclusions:

  • A multi-faceted approach involving exercise, nutrition, and pharmacotherapy is essential for osteoporosis management.
  • Medication choice depends on patient-specific factors and contraindications.
  • Ongoing research and safety monitoring are vital for effective osteoporosis treatment.