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Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
Antibacterial structure-activity relationship studies of several tricyclic sulfur-containing flavonoids
Lucian G Bahrin1, Henning Hopf2, Peter G Jones3
1Department of Chemistry, "Al. I. Cuza" University of Iasi, 11 Carol I Blvd., RO-700506 Iasi, Romania; Institute of Organic Chemistry, Technical University of Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.
Abstract:
A structure-activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have been synthesized by cyclocondensation of the corresponding 3-dithiocarbamic flavanones under acidic conditions. The influence of different halogen substituents on the antibacterial properties has been tested against Staphylococcus aureus and Escherichia coli. Amongst the N,N-dialkylamino-substituted flavonoids, those having an N,N-diethylamino moiety exhibited good to excellent antimicrobial properties against both pathogens. Fluorine-substituted flavonoids were found to be less active than those bearing other halogen atoms.
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