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A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

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302

The Antimicrobial and Cytotoxicity Properties of New Dibrominated 1,3-Dithiolium Flavonoids

Laura Gabriela Sarbu1, Ana Alexandra Dumitru2, Mihaela Savu2

  • 1Department of Chemistry, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, 700506 Iasi, Romania.

Pharmaceuticals (Basel, Switzerland)
|February 27, 2026
PubMed

Insights

Novel synthetic tricyclic flavonoids show potent antimicrobial activity against priority pathogens like Staphylococcus aureus and Acinetobacter baumannii. These compounds offer a promising new avenue for combating antimicrobial resistance (AMR).

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Microbiology

Background:

  • Antimicrobial resistance (AMR) is a major global health and socioeconomic challenge.
  • Contributing factors include antibiotic overuse, nosocomial infections, and a lack of new antibiotic classes.
  • Addressing AMR requires the development of novel antimicrobial agents.

Purpose of the Study:

  • To synthesize novel dibrominated tricyclic flavonoids.
  • To investigate the antimicrobial properties of these novel compounds.
  • To evaluate their cytotoxicity.

Main Methods:

  • Synthesis of novel dibrominated tricyclic flavonoids from 3-dithiocarbamic flavanones.
  • Antimicrobial activity testing against clinically relevant pathogens.
  • Cytotoxicity assays.

Main Results:

  • The synthesized tricyclic flavonoids demonstrated significant antimicrobial activity.
  • Potent activity was observed against Staphylococcus aureus, Acinetobacter baumannii, and Escherichia coli.
  • MIC and MBC values against S. aureus ATCC 25923 were as low as 0.12 µg/mL and 1.9 µg/mL, respectively.

Conclusions:

  • Synthetic tricyclic flavonoids possess strong antibacterial activity against WHO priority pathogens.
  • These compounds exhibit superior efficacy compared to natural/synthetic flavonoids and some conventional antibiotics.
  • The findings highlight the potential of these novel flavonoids in combating AMR.
Keywords:
ESKAPE pathogensbenzopyrandithiocarbamatessynthetic flavonoids

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