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Updated: Jun 14, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Iodine-Substituted Dithiocarbamic Flavanones-A Structure-Activity Relationship Study of Their Antioxidant Properties
Mihail Lucian Birsa1, Laura Gabriela Sarbu1
1Department of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol I Blvd., 700506 Iasi, Romania.
Novel diiodo-substituted 3-dithiocarbamic flavanones show potent antioxidant activity. Halogen substituents enhance radical scavenging, outperforming standard antioxidants like ascorbic acid and BHT.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
- Pharmacology
Background:
- Flavanones are a class of flavonoids with diverse biological activities.
- Previous studies identified active flavanone frameworks for further investigation.
- Structure-activity relationships are crucial for developing effective antioxidant compounds.
Purpose of the Study:
- To investigate the antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones.
- To perform a structure-activity relationship study on radical scavenging.
- To evaluate the influence of para-position substituents on antioxidant efficacy.
Main Methods:
- Synthesis of diiodo-substituted 3-dithiocarbamic flavanones.
- Structure-activity relationship analysis.
- Evaluation of radical scavenging activity using DPPH and ABTS assays.
Main Results:
- Halogen substituents (F, Cl, Br, H) were introduced at the para position of flavanone ring B.
- Diiodo-substituted flavanones exhibited superior antioxidant properties compared to ascorbic acid and BHT.
- Morpholine carbodithioates displayed the highest radical scavenging activity.
- All tested flavanones showed better antioxidant properties than BHT in the ABTS assay.
Conclusions:
- Diiodo-substituted 3-dithiocarbamic flavanones represent a promising class of antioxidants.
- Halogenation and specific substituents significantly enhance radical scavenging capabilities.
- These compounds hold potential for therapeutic applications requiring antioxidant effects.
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