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Updated: Mar 19, 2026
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
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Basosquamous Carcinoma: Controversy, Advances, and Future Directions
Caroline Z Tan1, Kerri E Rieger, Kavita Y Sarin
1Departments of *Dermatology, and †Pathology, School of Medicine, Stanford University, Redwood City, California.
Summary
Basosquamous carcinoma, a rare skin cancer, requires further research into its aggressive tumor formation mechanisms. This review summarizes current knowledge on its definition, pathogenesis, and management.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Basosquamous carcinoma is a rare cutaneous neoplasm with ongoing debate regarding its classification, pathogenesis, and management.
- Understanding this controversial tumor is crucial for effective clinical practice.
Purpose of the Study:
- To systematically review and synthesize current literature on basosquamous carcinoma.
- Key areas of focus include definition, pathogenesis, incidence, and management strategies.
Main Methods:
- An extensive electronic literature search was conducted using PubMed.
- Search terms included 'basosquamous carcinoma' and 'metatypical basal cell carcinoma' up to December 2015.
Main Results:
- Thirty-nine relevant publications were selected, encompassing case reports, series, retrospective studies, and systematic reviews.
- The review summarizes the definition, clinical behavior, histopathological features, current treatments, and potential future advancements for basosquamous carcinoma.
Conclusions:
- This systematic review offers a comprehensive overview of the current understanding of basosquamous carcinoma.
- Further investigation is necessary to fully elucidate the underlying mechanisms driving the development of this aggressive neoplasm.
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