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Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line

Shadi Mahdizadeh1, Gholamreza Karimi2, Javad Behravan3,4

  • 1Department of Cell and Molecular Biology, Kish International Campus, University of Tehran, Kish, Iran.

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
|June 26, 2016
PubMed
Abstract

Insights

Crocin, a saffron compound, reduces ovarian cancer cell growth and drug resistance by downregulating multidrug resistance-associated proteins (MRP1 and MRP2). This suggests crocin

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Oncology

Background:

  • Crocin, a key saffron component, exhibits anti-cancer properties.
  • Multidrug resistance-associated proteins 1 and 2 (MRP1 and MRP2) contribute to chemotherapy failure in cancer treatment.

Purpose of the Study:

  • To investigate the impact of crocin on MRP1 and MRP2 expression and function.
  • To evaluate crocin's effect on drug resistance in human ovarian cancer cells.

Main Methods:

  • Cytotoxicity assessed using MTT assay.
  • Gene expression analyzed via real-time RT-PCR.
  • Protein function evaluated through MTT assays.

Main Results:

  • Crocin inhibited cell proliferation in a dose-dependent manner, with greater effect on sensitive cells.
  • Crocin decreased MRP1 and MRP2 mRNA levels in resistant cells.
  • Crocin enhanced doxorubicin's cytotoxicity in resistant ovarian cancer cells.

Conclusions:

  • Crocin demonstrates potential to overcome drug resistance in ovarian cancer.
  • Downregulation of MRP transporters by crocin contributes to suppressing multidrug resistance.
Keywords:
A2780A2780/RCISCrocinMRP1MRP2Multidrug resistance

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