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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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[CD36 Antigen Deficiency and Platelet Transfusion]

Hai-Yan Li1, Yan Zhou1, Wei-Dong Shen1

  • 1Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning 530007, Guangxi Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|June 26, 2016
PubMed

CD36 is a transmembrane glycoprotein, a multi-ligand receptor, possesses various biological functions. CD36 deficiency may stimulate the body to produce anti-CD36 alloimmune antibodies through the several pathways, such as blood transfusion, pregnancy or organ transplantation and so on, leading to the refractoriness of immune platelet transfusion and other diseases. The recent research advances of CD36 deficiency and its molecular biological basis, platelet transfusion and CD36 antibody detection are summarized briefey in this review.

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