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In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

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The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.

Stefanie Koidl1, Nathalie Eisenhardt1, Chronis Fatouros1

  • 1Max Planck Institute of Immunobiology and Epigenetics, Department of Epigenetics, 79108 Freiburg, Stübeweg 51, Germany.

The International Journal of Biochemistry & Cell Biology
|June 26, 2016
PubMed
Summary

ZNF451-1 acts as a SUMO2/3 specific E3 ligase for PML, regulating PML levels and PML body numbers. This finding sheds light on the role of ZNF451-1 in maintaining cell homeostasis.

Keywords:
PMLRNF4SIMSUMO2/3ZNF451

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