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Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes

Thomas Reid Alderson1, Jin Hae Kim2, John Lute Markley2

  • 1Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, UK; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Structure (London, England : 1993)
|June 28, 2016
PubMed
Summary

Molecular chaperones heat shock protein 70 kDa (Hsp70) and Hsp40 prevent toxic protein aggregation. Structural biology and nuclear magnetic resonance reveal how these proteins maintain cellular protein homeostasis.

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