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Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

In Vivo Evaluation of Customized Aortic Repair Using a Novel Survival Model.

B M Doorschodt¹, H L Brom², A C de Vries³

¹Institute for Laboratory Animal Science & Experimental Surgery, RWTH-Aachen University, Aachen, Germany.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery

|June 28, 2016

Summary

The novel Customized Aortic Repair (CAR) method shows feasibility for endovascular aneurysm repair. This technique demonstrated mid-term biological safety in a sheep model, with biocompatible polymer use.

Keywords:

Abdominal aortic aneurysm Aneurysm sac filling Endovascular aneurysm repair In vivo study

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Last Updated: Mar 18, 2026

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Published on: October 20, 2023

Modified Heterotopic Abdominal Heart Transplantation and a Novel Aortic Regurgitation Model in Rats

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Published on: June 2, 2023

A New Murine Model of Endovascular Aortic Aneurysm Repair

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

Area of Science:

Biomedical Engineering
Vascular Surgery
Materials Science

Background:

Endovascular aneurysm repair (EVAR) is a minimally invasive treatment for aortic aneurysms.
Current EVAR methods may have limitations in complex anatomies.
A novel approach using custom-designed devices and in situ polymerizable materials is being explored.

Purpose of the Study:

To evaluate the feasibility of the Customized Aortic Repair (CAR) method for endovascular aneurysm treatment.
To assess the mid-term biological behavior and safety of the CAR technique in an animal model.

Main Methods:

A novel Customized Aortic Repair (CAR) technique involving a custom balloon and in situ polymer filling was developed.
A sheep model with surgically created carotid artery aneurysms was used for evaluation.
Animals were monitored for 20 weeks using duplex sonography and histological analysis.

Main Results:

Successful aneurysm exclusion was achieved in 4 out of 6 animals.
The polymer cast demonstrated biocompatibility and non-thrombogenicity without migration or expansion.
No polymer emboli were detected in critical outflow tracts.

Conclusions:

The Customized Aortic Repair (CAR) method is feasible for minimally invasive aneurysm repair.
Mid-term biological safety was demonstrated in a simulated aneurysm survival model.
Further investigation into CAR for complex aortic aneurysms is warranted.