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Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
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A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study.

Katie Paul Friedman1, Sabitha Papineni2, M Sue Marty3

  • 1a Human Safety, Bayer CropScience LP, Research Triangle Park , NC , USA ;

Critical Reviews in Toxicology
|June 28, 2016
PubMed
Summary
This summary is machine-generated.

High-throughput screening (HTS) and toxicology data can effectively prioritize chemicals for endocrine disruption testing. This approach, using triazole fungicides as an example, suggests low priority for further testing, protecting human health.

Keywords:
Endocrine Disruptor Screening ProgramExpoCastTox21ToxCasthigh-throughput screeningmyclobutanilpropiconazoletriadimefon

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Area of Science:

  • Environmental toxicology
  • Endocrine disruptor screening
  • High-throughput screening

Background:

  • The US Environmental Protection Agency Endocrine Disruptor Screening Program (EDSP) uses a tiered approach to assess chemical interactions with hormone systems.
  • High-throughput screening (HTS) is increasingly used to predict chemical hazards and exposure, shifting EDSP's focus to chemical prioritization and targeted assay use.

Purpose of the Study:

  • To evaluate toxicology data for three triazole fungicides (triadimefon, propiconazole, and myclobutanil) within the EDSP framework.
  • To assess the concordance between HTS predictions and EDSP Tier 1 requirements, incorporating mammalian toxicology data.

Main Methods:

  • Toxicology data, including HTS results and EPA guideline mammalian studies, were evaluated for three triazole fungicides.
  • Endocrine-related bioactivity predictions from HTS were compared with EDSP Tier 1 requirements and in vivo mammalian data.
  • Margins between predicted human bioactivity/exposure and EPA chronic human exposure estimates were calculated.

Main Results:

  • HTS predictions and EDSP Tier 1 requirements showed qualitative concordance for endocrine-related bioactivity.
  • Limitations in HTS for thyroid and steroidogenesis pathways were addressed by including guideline toxicology studies.
  • Similar margins (3-5 orders of magnitude) were found between HTS-predicted and in vivo mammalian bioactivity and exposure estimates.

Conclusions:

  • Combined HTS hazard and exposure predictions indicate a low priority for higher-tiered endocrine testing of these triazoles.
  • The HTS-based prioritization approach, supplemented with guideline toxicology, is protective of potential in vivo effects and human health.
  • This study demonstrates a viable roadmap for EDSP evaluation of pesticide active ingredients using HTS and toxicology data for prioritization.