Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

731
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
731
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.9K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.9K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

4.5K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.5K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

568
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
568
Arteries of the Head and Neck01:26

Arteries of the Head and Neck

4.1K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
4.1K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

3.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MIAAIM: Multi-omics image integration with dimensional reduction for tissue state mapping.

PLoS computational biology·2026
Same author

Atomoxetine plus oxybutynin for obstructive sleep apnoea: a randomised-controlled trial with detailed pathophysiology.

Thorax·2026
Same author

Treatment preferences for comorbid obesity and obstructive sleep apnea (PRO-CON OSA) survey: Patient and provider preferences for CPAP and/or tirzepatide.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same author

Banning sleep disparities research: A mentor's viewpoint.

Sleep health·2026
Same author

The Impact of Weight Loss on the Physiological Endotypes Associated With OSA.

Chest·2026
Same author

Research priorities to improve classification of sleep-wake disorders.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026

Related Experiment Video

Updated: Mar 18, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.8K

Obstructive Sleep Apnea and Vascular Diseases.

Dimitrios Baltzis1, Jessie P Bakker2, Sanjay R Patel2

  • 1Microcirculation Lab and Joslin-Beth Israel Deaconess Foot Center, Harvard Medical School, Boston, USA.

Comprehensive Physiology
|June 28, 2016
PubMed
Summary

Obstructive sleep apnea (OSA) is linked to vascular diseases due to intermittent hypoxia and sleep fragmentation. Interventions targeting OSA may reduce the risk of cardiovascular and cerebrovascular conditions.

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.7K

Related Experiment Videos

Last Updated: Mar 18, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.8K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.7K

Area of Science:

  • Physiology
  • Cardiovascular Science
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is prevalent in adults and recognized as an independent risk factor for cerebrovascular and cardiovascular diseases.
  • The pathophysiology of OSA involves repetitive airway obstruction leading to intermittent hypoxia, intrathoracic pressure swings, and sleep fragmentation.

Purpose of the Study:

  • To review the established associations between OSA and various vascular diseases.
  • To elucidate the underlying pathophysiological mechanisms linking OSA to micro- and macrocirculatory dysfunction.
  • To summarize interventional studies aimed at mitigating OSA and its vascular consequences.

Main Methods:

  • Literature review of observational and interventional studies.
  • Analysis of physiological mechanisms including sympathetic activation, oxidative stress, inflammation, and endothelial dysfunction.
  • Synthesis of evidence on the impact of OSA on both microcirculation and macrocirculation.

Main Results:

  • OSA is strongly associated with increased risk of stroke and heart disease.
  • Key mechanisms include intermittent hypoxia, sympathetic overactivity, inflammation, and endothelial dysfunction.
  • Interventional studies show potential for OSA treatment to improve vascular health.

Conclusions:

  • OSA significantly contributes to the development of vascular diseases through multiple interconnected pathways.
  • Understanding these mechanisms is crucial for developing effective therapeutic strategies.
  • Targeting OSA offers a promising approach to reduce the burden of cardiovascular and cerebrovascular diseases.