Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

795
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
795
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.6K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

309
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
309

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to Editorial Comment on "Genitourinary Fellowship for Family Medicine Physicians".

Urology·2025
Same author

Genitourinary Fellowship for Family Medicine Physicians.

Urology·2025
Same author

The Changing Role of a Chair and DA: Follow-Up from the 2023 ADFM Annual Conference Session.

Annals of family medicine·2024
Same author

Climate Change as a Threat to Health: Family Medicine Call to Action and Response.

Annals of family medicine·2023
Same author

A professional virtues-based ethical framework for medical missions.

AJOG global reports·2022
Same author

FROM ADFM: AMPLIFYING ADVOCACY IN FAMILY MEDICINE.

Annals of family medicine·2021

Related Experiment Video

Updated: Mar 18, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K

Eye Conditions in Older Adults: Open-Angle Glaucoma.

Tochi Iroku-Malize1, Scott Kirsch1

  • 1Department of Family Medicine Hofstra North Shore LIJ School of Medicine Southside Hospital, 301 East Main Street Bay Shore, NY 11706.

FP Essentials
|June 28, 2016
PubMed
Summary

Glaucoma, a leading cause of irreversible vision loss, is an optic neuropathy often detected by elevated intraocular pressure. Early detection and treatment are crucial for managing open-angle glaucoma, especially in older adults and minorities.

More Related Videos

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

4.4K

Related Experiment Videos

Last Updated: Mar 18, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

4.4K

Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Glaucoma is a primary cause of irreversible blindness in the US, affecting nearly 2% of adults over 40.
  • Open-angle glaucoma, the most common form, disproportionately impacts aging populations and non-Hispanic minorities.

Observation:

  • Vision loss in glaucoma patients often manifests as progressive peripheral vision impairment, increasing risks of falls and driving difficulties.
  • Glaucoma is characterized by optic nerve damage, often without early symptoms, leading to irreversible vision loss before detection.
  • Ophthalmoscopy revealing a cup to disc ratio exceeding 0.6 and visual field testing demonstrating peripheral loss are key indicators.

Findings:

  • Medical treatments, including prostaglandin analogs, beta blockers, alpha2-adrenergic agonists, and carbonic anhydrase inhibitors, aim to reduce intraocular pressure.
  • Surgical or laser interventions are considered when medical management proves insufficient for controlling intraocular pressure.
  • Alternative therapies present lower efficacy and higher adverse effect profiles compared to established glaucoma treatments.

Implications:

  • Effective management of intraocular pressure through medical or surgical means is vital for preventing further optic nerve damage and vision loss.
  • Public health initiatives should focus on early detection and management strategies, particularly for at-risk demographics.
  • Continued research into novel therapeutic approaches is necessary to improve outcomes for glaucoma patients.