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Related Concept Videos

Burn Injuries01:22

Burn Injuries

4.9K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Updated: Mar 18, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Direct Mouse Trauma/Burn Model of Heterotopic Ossification

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Predicting Heterotopic Ossification Early After Burn Injuries: A Risk Scoring System.

Jeffrey C Schneider1, Laura C Simko, Richard Goldstein

  • 1*Massachusetts General Hospital, Boston, MA †Shriners Hospitals for Children-Boston, Boston, MA ‡Spaulding Rehabilitation Hospital, Boston, MA §Harvard Medical School, Boston, MA ¶University of Michigan, Ann Arbor, MI ||Balliol College, University of Oxford, UK **University of Texas Southwestern Medical Center, Dallas, TX ††University of Texas Medical Branch, Galveston, TX ‡‡Shriners Hospital for Children-Galveston, Galveston, TX §§University of Washington, Seattle, WA.

Annals of Surgery
|June 28, 2016
PubMed
Summary

A new scoring system helps identify burn patients at risk for heterotopic ossification (HO). This tool aids in early diagnosis and potential prophylactic trials for this debilitating condition.

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Area of Science:

  • Burn injury research
  • Orthopedic complications
  • Medical scoring systems

Background:

  • Heterotopic ossification (HO) is a debilitating complication following burn injuries.
  • The exact mechanisms of HO in burns are not fully understood.
  • Currently, there are no universally effective prophylactic measures for HO in burn patients.

Purpose of the Study:

  • To develop a risk scoring system for heterotopic ossification (HO) in burn patients.
  • Stratify patients upon hospital admission based on HO risk.
  • Facilitate early identification for potential interventions.

Main Methods:

  • Utilized data from the Burn Model System National Database (1994-2010, n=3693).
  • Employed logistic regression to identify significant predictors of HO.
  • Developed and validated a 13-point risk scoring system.

Main Results:

  • Total body surface area (TBSA) burned and need for grafting in specific body regions were significant predictors of HO.
  • The developed risk scoring system demonstrated high predictive accuracy (c-statistic = 0.92).
  • Internal and external validation confirmed the model's robustness. An online calculator is available.

Conclusions:

  • The developed HO risk scoring system effectively stratifies burn patients.
  • Identifies high-risk individuals for targeted diagnostic testing.
  • Supports enrollment in interventional trials for HO prophylaxis.