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A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
Published on: October 17, 2016
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Poly(lactic acid) for delivery of bioactive macromolecules
Roshan James1, Ohan S Manoukian2, Sangamesh G Kumbar3
1The Raymond and Beverly Sackler Center for Biomedical, Biological, Engineering and Physical Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA; Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.
Advanced Drug Delivery Reviews
|June 29, 2016
Summary
Poly(lactic acid) (PLA) offers a versatile solution for delivering therapeutic biomolecules. This biodegradable material enhances drug circulation, stability, and targeting, overcoming limitations of traditional administration methods.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Therapeutic biomolecules often require frequent administration, leading to poor patient compliance and potential side effects.
- Direct administration can result in inadequate physiological response, mis-targeting, and severe adverse events.
- Existing delivery systems aim to increase circulatory time and biomolecule half-life, but often lack specificity.
Purpose of the Study:
- To discuss the challenges associated with therapeutic biomolecule delivery.
- To review classical and emerging Poly(lactic acid) (PLA)-based strategies for biomolecule delivery and targeting.
- To highlight the advantages of PLA as a versatile biomaterial for drug delivery applications.
Main Methods:
- Review of literature on Poly(lactic acid) (PLA) synthesis and fabrication techniques.
- Analysis of PLA's physicochemical properties relevant to drug encapsulation and release.
- Examination of various PLA-based delivery systems and targeting strategies in preclinical and clinical development.
Main Results:
- Poly(lactic acid) (PLA) is a highly customizable and biocompatible material suitable for drug delivery.
- PLA-based systems can enhance biomolecule stability, prolong circulation time, and improve cell/nucleus permeability.
- Innovations in PLA formulations enable highly specific cell targeting, reducing off-target effects.
Conclusions:
- Poly(lactic acid) (PLA) presents a promising platform for developing advanced biomolecule delivery systems.
- PLA's versatility allows for tailored drug delivery solutions to overcome current therapeutic challenges.
- Further development of PLA-based targeting strategies holds potential for improved treatment efficacy and safety.
Keywords:
BiomoleculeBlood–brain barrierClozapine (PubChem CID: 2818)DNADoxorubicin (PubChem CID: 31,703)NGR peptide (PubChem CID: 18,219,107)NanoparticlePaclitaxel (PubChem CID: 36,314)Penetratin (PubChem CID: 16,134,279)PeptidePolydimethylaminoethyl methacrylate (PubChem CID: 107,676)Polyethylene glycol (PubChem CID: 174)Polylactic acid (PubChem CID: 612)ProteinRNATargetingThyrotropin-releasing hormone (PubChem CID: 32,281)
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