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Determinants of Racial/Ethnic Differences in Cardiorespiratory Fitness (from the Dallas Heart Study)
Ambarish Pandey1, Bryan D Park1, Colby Ayers1
1Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Insights
Ethnic differences in cardiorespiratory fitness (CRF) are linked to body mass index (BMI), lifestyle, socioeconomic status (SES), and cardiovascular risk factors. These factors explain much of the observed disparities in CRF among different racial and ethnic groups.
Area of Science:
- Cardiovascular Health
- Exercise Physiology
- Health Disparities
Background:
- Ethnic and racial variations in cardiorespiratory fitness (CRF) are documented.
- The underlying determinants of these CRF differences, including lifestyle, socioeconomic status (SES), and cardiovascular (CV) risk factors, remain incompletely understood.
Purpose of the Study:
- To investigate the contributions of body mass index (BMI), lifestyle behaviors, SES, CV risk factors, and cardiac function to ethnic/racial differences in CRF.
Main Methods:
- Utilized data from 2,617 Dallas Heart Study participants without CV disease.
- Employed multivariable-adjusted linear regression models to assess the association between race/ethnicity and CRF (peak oxygen uptake).
- Adjusted for age, gender, BMI, lifestyle factors, SES, CV risk factors, and stroke volume.
Main Results:
- Black participants exhibited the lowest CRF compared to white and Hispanic participants.
- Initially, black and Hispanic participants showed significantly lower CRF after adjusting for age and gender.
- These associations were substantially attenuated or became non-significant after adjusting for BMI, lifestyle, SES, and CV risk factors.
- Adjustment for stroke volume did not significantly alter the association between black race/ethnicity and CRF.
Conclusions:
- BMI, lifestyle factors, SES, and traditional CV risk factors are key determinants of ethnic/racial disparities in cardiorespiratory fitness.
- These factors largely explain the observed differences in CRF across racial and ethnic groups.
Abstract:
Previous studies have demonstrated ethnic/racial differences in cardiorespiratory fitness (CRF). However, the relative contributions of body mass index (BMI), lifestyle behaviors, socioeconomic status (SES), cardiovascular (CV) risk factors, and cardiac function to these differences in CRF are unclear. In this study, we included 2,617 Dallas Heart Study participants (58.6% women, 48.6% black; 15.7% Hispanic) without CV disease who underwent estimation of CRF using a submaximal exercise test. We constructed multivariable-adjusted linear regression models to determine the association between race/ethnicity and CRF, which was defined as peak oxygen uptake (ml/kg/min). Black participants had the lowest CRF (blacks: 26.3 ± 10.2; whites: 29.0 ± 9.8; Hispanics: 29.1 ± 10.0 ml/kg/min). In multivariate analysis, both black and Hispanic participants had lower CRF after adjustment for age and gender (blacks: Std β = -0.15; p value ≤0.0001, Hispanics: Std β = -0.05, p value = 0.01; ref group: whites). However, this association was considerably attenuated for black (Std β = -0.04, p value = 0.03) and no longer significant for Hispanic ethnicity (p value = 0.56) after additional adjustment for BMI, lifestyle factors, SES, and CV risk factors. Additional adjustment for stroke volume did not substantially change the association between black race/ethnicity and CRF (Std β = -0.06, p value = 0.01). In conclusion, BMI, lifestyle, SES, and traditional risk factor burden are important determinants of ethnicity-based differences in CRF.
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