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Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
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Obesity and hypomagnesemia.

Fernando Guerrero-Romero1, Araceli Flores-García1, Stephanie Saldaña-Guerrero1

  • 1Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas # 100, Col. Los Angeles, ZC 34067, Durango, Mexico.

European Journal of Internal Medicine
|June 30, 2016
PubMed
Summary

Low serum magnesium is not linked to body weight status in healthy adults. Instead, hyperglycemia, not obesity, is a significant cause of hypomagnesemia, regardless of body mass index.

Keywords:
HyperglycemiaHypomagnesemiaNormal weightObesityOverweight

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Area of Science:

  • Clinical Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • The relationship between low serum magnesium (hypomagnesemia) and obesity is not fully understood.
  • It remains unclear if hypomagnesemia is a consequence of obesity or an independent factor.

Purpose of the Study:

  • To investigate the association between body weight status and hypomagnesemia in healthy individuals.
  • To clarify the role of body mass index (BMI) in the development of hypomagnesemia.

Main Methods:

  • A cross-sectional study of 681 healthy adults (aged 30-65) was conducted.
  • Participants were categorized by Body Mass Index (BMI) into normal weight, overweight, and obese.
  • Hypomagnesemia was defined as serum magnesium ≤0.74mmol/L; logistic regression analysis was used.

Main Results:

  • Multivariate analysis indicated dietary magnesium intake was associated with hypomagnesemia, but not obesity, overweight, or normal weight status.
  • Further analysis adjusted for BMI and other metabolic factors showed hyperglycemia and low dietary magnesium intake remained significant predictors of hypomagnesemia.

Conclusions:

  • Body weight status (including obesity) is not independently associated with hypomagnesemia in healthy individuals.
  • Hyperglycemia is identified as a cause of hypomagnesemia in non-diabetic individuals, independent of body weight.