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How and when to prescribe sodium fluoride
1Department of Otolaryngology, Northwestern University, Chicago, Illinois.
The American Journal of Otology
|March 1, 1989
Summary
Sodium fluoride effectively treats otosclerosis by promoting bone maturation and slowing sensorineural hearing loss progression. Clinical studies confirm its safety and efficacy in patients with otosclerosis and after stapedectomy.
Area of Science:
- Otolaryngology
- Pharmacology
- Bone Metabolism
Background:
- Sensorineural hearing loss is a common complication of otosclerosis and stapedectomy.
- Sodium fluoride has been used for over two decades to manage these conditions.
- Previous objections cited a lack of robust clinical evidence.
Purpose of the Study:
- To evaluate the efficacy of sodium fluoride in arresting sensorineural hearing loss.
- To confirm the therapeutic value of sodium fluoride through rigorous scientific studies.
Main Methods:
- Review of extensive clinical experience with sodium fluoride therapy.
- Analysis of double-blind, placebo-controlled studies (Bretlau, Fisch).
- Examination of research on sodium fluoride's effect on bone metabolism (Petrovic) and otospongiotic lesions (Linthicum, House, Althaus).
Main Results:
- Clinical data from thousands of patients demonstrate sodium fluoride's ability to arrest progressive sensorineural hearing loss.
- Double-blind studies confirm the efficacy of sodium fluoride.
- Research shows sodium fluoride promotes the maturation of otospongiotic lesions.
Conclusions:
- Sodium fluoride is a valuable, effective, and safe medication for treating otosclerosis.
- It effectively promotes the maturation of otospongiotic lesions.
- Sodium fluoride can slow or arrest the progression of sensorineural hearing loss.