Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

10.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.2K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.8K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.8K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

9.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.9K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.9K
Overview
85.9K
Immunological Memory01:23

Immunological Memory

17.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction.

bioRxiv : the preprint server for biology·2026
Same author

Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes.

Science immunology·2025
Same author

The transcription factor BCL11B drives NK cell cytotoxicity and antitumor activity.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

No Association Between HLH-associated Gene Variants and Life-Threatening COVID-19.

Journal of clinical immunology·2025
Same author

Clinical spectrum of primary hemophagocytic lymphohistiocytosis: experience of reference centers in Central and Southeast Anatolia.

Annals of hematology·2024
Same author

Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.

Nature immunology·2024
Same journal

Myeloid cells as sources and targets of IL-1 family cytokines in cancer.

Seminars in immunology·2026
Same journal

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?

Seminars in immunology·2026
Same journal

Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics.

Seminars in immunology·2026
Same journal

Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity.

Seminars in immunology·2026
Same journal

The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives.

Seminars in immunology·2026
Same journal

Introduction to the special issue: T<sub>H</sub>9 cells in diseases.

Seminars in immunology·2026
See all related articles

Related Experiment Video

Updated: Mar 18, 2026

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
06:55

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Published on: February 22, 2020

19.6K

Natural killer cell memory in context.

Tim D Holmes1, Yenan T Bryceson1

  • 1Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway.

Seminars in Immunology
|June 30, 2016
PubMed
Summary
This summary is machine-generated.

Immune memory is not exclusive to T and B cells. Research reveals diverse NK cell memory subsets in mice and humans, offering insights into non-classical immune memory mechanisms.

Keywords:
AdaptiveCMVEpigeneticImmunological memoryMechanismsNK cell

More Related Videos

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
06:53

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells

Published on: January 13, 2023

3.7K
Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
11:02

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

6.5K

Related Experiment Videos

Last Updated: Mar 18, 2026

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
06:55

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Published on: February 22, 2020

19.6K
Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
06:53

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells

Published on: January 13, 2023

3.7K
Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
11:02

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

6.5K

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Immune memory is traditionally linked to T and B lymphocytes.
  • Alternative immune memory strategies exist across species and cell types.
  • Natural Killer (NK) cell memory subsets are increasingly recognized.

Purpose of the Study:

  • To explore the existence and mechanisms of NK cell memory.
  • To investigate NK cell memory in the context of cytomegalovirus infection.
  • To compare NK cell memory in murine and human models.

Main Methods:

  • Utilizing mouse models of cytomegalovirus infection.
  • Identifying and characterizing NK cell subsets in murine and human livers.
  • Analyzing epigenetic alterations in human NK cell expansions.

Main Results:

  • Long-lived NK cell memory identified in mouse models.
  • Murine liver-resident memory NK cells show potential antigen-specificity.
  • Phenotypic counterparts and epigenetic alterations found in human liver NK cells.

Conclusions:

  • A spectrum of NK cell memory subsets exists in primates.
  • Epigenetic changes influence NK cell phenotype and function.
  • Common mechanisms may underlie NK cell memory and non-classical immune memory.