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Sleep restriction acutely impairs glucose tolerance in rats

Pawan K Jha1, Ewout Foppen2, Andries Kalsbeek3

  • 1Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands Regulation of Circadian Clocks team, Institute of Cellular and Integrative Neurosciences UPR3212 Centre National de la Recherche Scientifique (CNRS) University of Strasbourg, Strasbourg, France International Associated Laboratory LIA1061 Understanding the Neural Basis of Diurnality, CNRS, France and the Netherlands kj.pawan@gmail.com.

Physiological Reports
|June 30, 2016
PubMed
Summary

Short sleep deprivation impairs glucose tolerance in rats by reducing insulin response. This acute sleep restriction negatively affects glucose homeostasis, even without changes in basal glucose or insulin levels.

Keywords:
Glucose tolerancesleep deprivationsuprachiasmatic nucleustype 2 diabetes

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