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Updated: Mar 18, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
Published on: July 23, 2016
Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine
Dongsheng Yang1, Yuhuan Li2, Yuhang Qi2
1College of Animal Science, Jilin University, Changchun, Jilin, P.R. China Department of Chemistry and Pharmacy, Zhuhai College of Jilin University, Zhuhai, Guangdong, P.R. China.
Abstract:
Cationic liposomes incorporating stearic acid-modified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself.
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