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Related Concept Videos

Brain Imaging01:14

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Can irisin be a linker between physical activity and brain function?

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    PubMed
    Summary
    This summary is machine-generated.

    Irisin, a hormone released by muscles during exercise, impacts brain function, neuroprotection, and memory. This myokine may mediate communication between muscles and the central nervous system.

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    Area of Science:

    • Exercise physiology
    • Neuroendocrinology
    • Metabolic research

    Background:

    • Irisin is a myokine released from skeletal muscle during exercise.
    • It is known to improve obesity and glucose dysfunction by promoting adipose tissue browning.
    • Emerging evidence suggests irisin also plays a role in brain function.

    Purpose of the Study:

    • To review the current understanding of irisin's neuronal functions.
    • To discuss irisin's potential role as a messenger between skeletal muscle and the central nervous system (CNS).

    Main Methods:

    • Review of existing scientific literature on irisin and its effects on the brain.
    • Analysis of studies investigating FNDC5 mRNA and irisin presence in the brain.
    • Examination of research on irisin's impact on neuroprotection, learning, memory, and behavior.

    Main Results:

    • FNDC5 mRNA and irisin are found in various brain regions.
    • Central irisin influences neural differentiation, proliferation, neurobehavior, energy expenditure, and cardiac function.
    • Elevated peripheral irisin levels enhance hippocampal genes associated with neuroprotection, learning, and memory.

    Conclusions:

    • Irisin has significant neuronal functions beyond its metabolic effects.
    • Irisin may act as a crucial mediator in the crosstalk between skeletal muscle and the CNS during exercise.
    • Further research is warranted to fully elucidate the therapeutic potential of irisin.