[Serological diagnosis methods of schistosomiasis japonica at different prevalence: a meta-analysis]

To comprehensively evaluate the effects of indirect hemagglutination test (IHA) , enzyme-linked immunosorbent assay (ELISA), and dipstick dye method (DDIA) in the diagnosis of schistosomiasis japonica at different prevalence by using Meta-analysis.

Through the literature review according to the inclusion and exclusion criteria, a database was established, and by using Meta-disc and R software, the Meta-analysis was performed including the threshold test, heterogeneity test, weighted by the quantitative effect of merger, SROC curve fitting, etc.

A total of 60 papers were included in the final analysis. The sensitivities of IHA were 0.84, 0.76 and 0.94 in heavy, medium and low endemic areas, and specificities were 0.73, 0.64 and 0.73 respectively; the sensitivities of ELISA were 0.88, 0.80 and 0.93 in heavy, medium and low endemic areas, and the specificities were 0.59, 0.59 and 0.62 respectively; the sensitivities of DDIA were 0.93, 0.81 and 0.93 in the heavy, medium and low endemic areas, and specificities were 0.66, 0.69 and 0.59 respectively. The weighted sensitivities of IHA, ELISA and DDIA were 0.83, 0.87 and 0.90 respectively; the weighted specificities were 0.69, 0.60 and 0.62 respectively. The areas under the curve of SROC were 0.89, 0.96 and 0.92 in IHA, ELISA and DDIA respectively.

In different prevalence, the effectiveness of different methods for serological diagnosis of schistosomiasis is different. The sensitivity and specificity of all diagnostic methods of schistosomiasis need to further improve.