Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of nano-silver small intestine submucosa repair of osteochondral defect in rabbit model by the AMPK-mTOR-ULK1 pathway.

Hereditas·2026
Same author

Genome Variation in Alcohol Use Disorder by Whole-Exome Sequencing.

Addiction biology·2025
Same author

Leveraging readily available clinical data with machine learning to predict first-line immunotherapy outcomes in non-small cell lung cancer.

International immunopharmacology·2025
Same author

Investigating the Citrus Aphid Species in Zhejiang, China: Morphometric Analysis and Genetic Distinctions.

Neotropical entomology·2025
Same author

Scaling laws of bacterial and archaeal plasmids.

Nature communications·2025
Same author

Unlocking the Potential of MOFs Anodes via Solid-State Corrosion Prelithiation for High-Energy Li-Ion Batteries.

Advanced materials (Deerfield Beach, Fla.)·2025

Related Experiment Video

Updated: Mar 18, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

6.9K

Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review).

Jia Lu1, Qian-Qian Wu, Ya-Bo Zhou

  • 1School of Basic Medical Hebei Medical University, Beijing, China E-mail : liuweihebmu@hebmu.edu.cn, zhengwei301@sina.cn.

Asian Pacific Journal of Cancer Prevention : APJCP
|July 1, 2016
PubMed
Summary

The CKLF-like MARVEL transmembrane domain-containing family (CMTM) genes are potential tumor suppressors involved in immune and reproductive systems. Research shows CMTMs are linked to cancer development and metastasis, offering diagnostic and therapeutic potential.

More Related Videos

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.8K
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.9K

Related Experiment Videos

Last Updated: Mar 18, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

6.9K
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.8K
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.9K

Area of Science:

  • Genetics and Molecular Biology
  • Cancer Research
  • Immunology

Background:

  • The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a newly identified gene family.
  • CMTM gene products exhibit characteristics of both chemokines and the transmembrane-4 superfamily.
  • These genes are located on various human chromosomes and are implicated in several biological systems.

Purpose of the Study:

  • To investigate the role of CMTM genes in tumorigenesis, tumor development, and metastasis.
  • To explore the potential of CMTMs as tumor suppressor genes.
  • To understand the clinical significance of CMTMs in diseases related to the tumor and immune systems.

Main Methods:

  • Gene expression analysis in tumor samples (implied).
  • Bioinformatic analysis of CMTM gene family.
  • Literature review of studies on CMTMs and associated diseases.

Main Results:

  • CMTM genes are found to be dysregulated in various tumors.
  • A strong association between the CMTM family and cancer development, including metastasis, has been identified.
  • CMTMs play significant roles in the immune, male reproductive, and hematopoietic systems.

Conclusions:

  • CMTMs are potential tumor suppressor genes with implications in cancer.
  • The CMTM family is closely linked to tumorigenesis and cancer progression.
  • CMTMs hold significant clinical value for diagnosing and treating cancers and immune-related diseases.