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Asenapine: A Review in Schizophrenia
Greg L Plosker1, Emma D Deeks2
1Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand.
CNS Drugs
|July 1, 2016
Summary
Asenapine is an atypical antipsychotic effective for schizophrenia symptoms, showing benefits in short-term and long-term studies. While generally well-tolerated, it may cause somnolence and akathisia, but has fewer metabolic issues than olanzapine.
Area of Science:
- Pharmacology and Psychiatry
- Clinical Therapeutics
- Schizophrenia Treatment
Background:
- Asenapine is an atypical antipsychotic administered sublingually for schizophrenia.
- It is approved in the USA and Japan, but not the EU.
- This review covers asenapine's pharmacology, efficacy, and tolerability in adult schizophrenia.
Purpose of the Study:
- To review the pharmacology, clinical efficacy, and tolerability of asenapine.
- To evaluate asenapine's effectiveness in treating positive and negative symptoms of schizophrenia.
- To compare asenapine's adverse event profile with other antipsychotics.
Main Methods:
- Review of clinical trials and meta-analyses of asenapine in schizophrenia.
- Assessment of short-term and long-term efficacy data.
- Analysis of reported adverse events and tolerability profiles.
Main Results:
- Asenapine demonstrated efficacy over placebo in short-term acute schizophrenia trials.
- Longer-term studies showed asenapine effective in relapse prevention but less so than olanzapine.
- Asenapine showed comparable efficacy to olanzapine for negative symptoms, with potential advantages in longer-term treatment.
Conclusions:
- Asenapine is effective for positive and negative symptoms of schizophrenia.
- It presents a favorable metabolic profile compared to some other antipsychotics.
- Common adverse events include somnolence, akathisia, and oral hypoesthesia.
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