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Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights

Yamei Chen1, Delong Liu1

  • 11 Department of Hematology, Xiamen Zhongshan Hospital, Xiamen 361001, China ; 2 Henan Tumor Hospital, Zhengzhou University, Zhengzhou 450003, China.

Stem Cell Investigation
|July 1, 2016
PubMed

Hematopoietic stem cells (HSCs) can take one of the three different pathways: quiescence, self-renewal and differentiation. Mechanisms that control the tight balance to maintain lifelong hematopoietic homeostasis have been a major interest of research. Platelet factor-4 (PF4), a weak chemokine, is synthesized exclusively by megakaryocytes and sequestered in platelets. This meeting report highlights a novel study presented at 2013 ASH annual meeting. This study found that megakaryocyte, a progeny of HSC, was involved in maintaining quiescence of HSCs via PF4 in a feedback loop.

Keywords:
Hematopoietic stem cell (HSC)megakaryocytesplatelet factor-4 (PF4)

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