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Leucoencephalomyelopathy in Australian Rottweiler dogs.

R F Slocombe1, R Mitten, T A Mason

  • 1Veterinary Clinical Centre, University of Melbourne, Werribee, Victoria.

Australian Veterinary Journal
|May 1, 1989
PubMed
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A novel canine neurological disorder, leucoencephalomyelopathy, was identified in Rottweilers. This condition involves spinal cord demyelination and is likely a genetically inherited trait.

Area of Science:

  • Veterinary Neurology
  • Canine Pathology

Background:

  • Neurological disorders in dogs can significantly impact quality of life.
  • Rottweilers may be predisposed to specific neurological conditions.
  • Accurate diagnosis is crucial for effective management and understanding disease mechanisms.

Purpose of the Study:

  • To describe a newly identified neurological disorder in adult Rottweiler dogs.
  • To characterize the clinical and pathological features of this condition.
  • To investigate the potential cause and transmission of the disorder.

Main Methods:

  • Clinical examination of affected dogs, including neurological assessments.
  • Analysis of blood and cerebrospinal fluid (CSF).
  • Diagnostic imaging including radiography and myelography.

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  • Gross and microscopic pathological examination of the central nervous system (CNS) post-necropsy.

    • Main Results:

    • Dogs exhibited proprioceptive deficits, ataxia, and hypermetria.
    • Routine blood and CSF analyses were unremarkable.
    • Imaging ruled out compressive spinal cord lesions.
    • Necropsy revealed severe, symmetrical demyelination in the spinal cord and brain white matter tracts.
    • Axons were spared in affected areas, consistent with leucoencephalomyelopathy.

    Conclusions:

    • The described condition is diagnosed as leucoencephalomyelopathy.
    • This is the first report of leucoencephalomyelopathy in Australia.
    • The disorder is likely inherited, potentially as an autosomal recessive trait.