Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

357
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
357
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

269
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
269
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

332
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
332
Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

1.5K
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.5K
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.7K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of intractable pruritus with maralixibat in patients with Alagille syndrome before and after reversal of biliary diversion.

JPGN reports·2025
Same author

Reply: Chronic rejection in Black pediatric transplant recipients-A call for medical social work integration.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2025
Same author

The Society of Pediatric Liver Transplantation (SPLIT): 2023 Registry Status.

Pediatric transplantation·2025
Same author

Efficacy, safety, and tolerability of chenodeoxycholic acid (CDCA) in adult patients with cerebrotendinous xanthomatosis (RESTORE): A randomized withdrawal, double-blind, placebo-controlled, crossover phase-3 study.

Genetics in medicine : official journal of the American College of Medical Genetics·2025
Same author

Cytomegalovirus prophylaxis in pediatric liver transplantation: A comparison of strategies across the Society of Pediatric Liver Transplantation (SPLIT) consortium.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2024
Same author

Incidence and risk factors for chronic rejection in pediatric liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2024

Related Experiment Video

Updated: Mar 18, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.4K

Gastrointestinal Conditions in the Obese Patient.

Sharonda Alston Taylor, Ryan Himes, Elisabeth Hastings

    Adolescent Medicine: State of the Art Reviews
    |July 2, 2016
    PubMed
    Summary

    Adolescent obesity poses challenges, particularly gastrointestinal (GI) issues. Effective management requires understanding GI complications, treatment options, and behavioral interventions like motivational interviewing (MI).

    Area of Science:

    • Pediatric Gastroenterology
    • Adolescent Medicine
    • Obesity Medicine

    Background:

    • Adolescent obesity is a growing concern with significant health implications.
    • Gastrointestinal (GI) complications are common in obese adolescents.
    • Effective management strategies are crucial for improving patient outcomes.

    Purpose of the Study:

    • To outline the challenges associated with adolescent obesity and its GI manifestations.
    • To provide a framework for understanding the pathophysiology and clinical presentations of GI issues in obese youth.
    • To highlight effective approaches for managing these complications, including pharmacotherapy and behavioral interventions.

    Main Methods:

    • Review of current literature on adolescent obesity and GI complications.

    More Related Videos

    An Acupoint Catgut-embedding Therapy for Treating Obesity
    04:50

    An Acupoint Catgut-embedding Therapy for Treating Obesity

    Published on: April 4, 2025

    1.8K
    Sleeve Gastrectomy in Mice using Surgical Clips
    05:16

    Sleeve Gastrectomy in Mice using Surgical Clips

    Published on: November 14, 2020

    7.5K

    Related Experiment Videos

    Last Updated: Mar 18, 2026

    Multidisciplinary Approach to Obesity Management: A Case Report
    05:10

    Multidisciplinary Approach to Obesity Management: A Case Report

    Published on: May 30, 2025

    1.4K
    An Acupoint Catgut-embedding Therapy for Treating Obesity
    04:50

    An Acupoint Catgut-embedding Therapy for Treating Obesity

    Published on: April 4, 2025

    1.8K
    Sleeve Gastrectomy in Mice using Surgical Clips
    05:16

    Sleeve Gastrectomy in Mice using Surgical Clips

    Published on: November 14, 2020

    7.5K
  • Discussion of diagnostic and laboratory evaluation methods.
  • Exploration of pharmacotherapeutic and behavioral treatment strategies, including motivational interviewing (MI).

    • Main Results:

    • Obesity in adolescents leads to diverse GI problems requiring specialized medical attention.
    • A comprehensive understanding of pathophysiology and clinical presentations aids in effective management.
    • Pharmacotherapy and behavioral interventions like MI are key components of successful treatment plans.

    Conclusions:

    • Physicians managing obese adolescents need a thorough understanding of potential GI complications.
    • Integrated management approaches combining medical, pharmacological, and behavioral strategies are essential.
    • Motivational interviewing (MI) is a valuable tool for facilitating behavioral change in this population.